Bringing the biological ground truth to AI.

CODEBREAKER LABS is pioneering Causal Genomics—empirically mapping the real-world effects of genetic variants at scale. Associations whisper. Causation speaks.

We’re not just interpreting biology, we’re programming it—building the foundation for AI that transforms medicine and accelerates breakthroughs in human health.

DATA AND PRODUCTS

our data: codex of variant profiles

At Codebreaker, we’re building the world’s largest dataset of causal variant effects on human cell behavior. Our proprietary synthetic biology platform programs cells with 10,000s of genomic variants in parallel—then uses single-cell assays (e.g. omics) to deeply fingerprint their phenotypic impact in relevant cell types (e.g. primary cells). This unlocks a molecular-level view of how genetic variation actually alters function, in real time.

The result? A continuously expanding Codex of experimentally validated variant profiles—a compounding dataset designed to train AI not just to recognize patterns, but to understand cause and effect.

Arlington AI: CDS SOFTWARE

Arlington AI is a next-generation clinical decision support system built to unlock the full power of WGS and WES. Unlike conventional tools, Arlington integrates your patient’s genomic data with Codebreaker’s Codex of Variant Profiles—a growing library of experimentally validated variant effects—and our proprietary predictive AI.

The result? Faster, more accurate interpretation of rare and challenging cases, including those that elude even expert review.

ARLINGTON AI: INSIGHTS (coming soon)

AI alone doesn’t discover drugs—biology does. Codebreaker provides proprietary data on genetic variants that can cause disease phenotypes through functional validation. Algorithmic predictions driven only by correlative data can be prone to hallucination - - Codebreaker offers the ground truth data leading to validated mechanisms.

The result? A powerful platform for identifying new drug targets, segmenting patients by functional biology, and de-risking development through causal evidence—not just predictions.

Our story

Codebreaker was born from two enduring frustrations—one scientific, one deeply human.

For decades, our founders pioneered breakthroughs in genome engineering, synthetic biology, and functional genomics. They built platforms to program biology at scale—yet always encountered the same obstacle: sequencing was abundant, but the overwhelming majority of genomic variants remained uninterpretable. The complexity of the genome consistently outpaced our ability to map function.

That gap carried real human costs. In clinics, we watched families wait months or years—sometimes forever—for answers hidden in genetic data. Whole genome sequencing promised clarity, but too often delivered uncertainty instead of solutions.

So we asked: What if we could directly generate the biological ground truth at scale?

Codebreaker exists to answer that question. We are building the world’s first causal genomics platform in human primary cells—a foundation of experimentally validated insights that power AI grounded in biology. With our continuously expanding Codex of Variant Profiles, we transform unknown variants into clinical answers, accelerating care and discovery for those who need them most.

OUR TEAM

  • Co-Founder and CEO

    Ryan Gill is a pioneer in programmable biology with more than 25 years at the forefront of genome engineering. He co-founded and led Inscripta, first as founding CEO and later as CSO, where he helped grow the company into a global leader in CRISPR-based platforms. As CEO of Artisan Biosciences, he guided the company through five years of successful collaborations with leading biopharma partners.

    Across these ventures, Ryan helped develop some of the most widely recognized tools for editing and understanding the human genome. He is the author of over 200 publications and patents and has built internationally respected academic programs in synthetic biology.

    Today, his combined scientific and executive leadership anchors Codebreaker’s mission to turn genomic complexity into clinical and therapeutic clarity.

  • Co-Founder and CTO

    Tanya Warnecke-Gill is a multi-time founder and technology leader who has spent her career building platforms at the forefront of genome engineering. As CTO at Inscripta and Artisan Biosciences, she helped pioneer award-winning CRISPR technologies and translate breakthrough concepts into scalable, real-world platforms.

    She is the inventor on dozens of patents and has consistently driven the translation of novel genome engineering methods into protected, commercially viable technologies. At Codebreaker, Tanya leads development of the company’s causal genomics platform, ensuring it delivers the scale, precision, and impact needed to transform genomic medicine.

    With 35+ patents and a deep track record in productizing genomic innovation, Tanya brings the technical vision and executional rigor that power Codebreaker’s synthetic biology engine. She leads the development of the Codex platform, ensuring it is built for scale, precision, and lasting impact.

  • Co-Founder and Chief Data Advisor

    As a computational biologist and professor with appointments in Computer Science and the BioFrontiers Institute at the University of Colorado, Ryan brings the AI and data science leadership necessary to extract meaning from the complexity of genomic data.
    He is a recognized expert in variant interpretation, large-scale sequencing, and functional annotation, having developed foundational tools used across clinical genomics. Ryan leads the development of Codebreaker’s AI models, ensuring they are grounded not just in computation—but in experimentally validated biological truth.

  • Codebreaker is guided by a world-class advisory group of scientific, clinical, and industry leaders. From pioneers in synthetic biology, functional genomics, and human genetics to executives who have scaled global biopharma organizations, our advisors bring unmatched expertise in translating breakthrough science into real-world impact. Their collective experience ensures that Codebreaker’s causal genomics platform is built with both scientific rigor and clinical relevance.

Interested in collaborating? We are actively filling our Codex Pioneers Program (Arlington AI: Codex and CDS) and looking for collaborators with an interest in functional variant data for building superior AI.